Th17 cells and IL-17, have also been shown to be decreased, with calcitriol (1,25(OH)2D) reducing IL-17 production in a mouse colitis model and impairing commitment to the Th17 lineage in mice with experimental autoimmune uveitis [157,158], although these effects may not translate to the human respiratory system. The gene discussed is IL17A; the disease is autoimmune uveitis.