ICAM1 and myocardial infarction: Moreover, we proved that the ICAM-1-targeted microbubbles are a more effective and feasible gene carrier for myocardial infarction gene therapy than common microbubbles, as their use increases the chance of the release of more bubbles to the area of interest and exerts better bioeffects, as determined by the standard of the effects of the direct IMI which is recognized as the most efficient method for exogenous gene transfection.