To determine if the reconstituted human cells in DRAG mice are susceptible to in vitro HIV-1 infection, cells were isolated from the FRT and gut (IEL, LPL, and PP), stimulated, infected with 2.2 × 103 infectious units of HIV-1 (US-1, 0.5 ng of p24), and then cultured for 48 hours as described in the Materials and Methods Section. The gene discussed is LPL; the disease is HIV-1 infection.