Some studies have noted a poor prognosis for SALL4-positive HCC (Yong et al. 2013; Zeng et al. 2014; Liu et al. 2014), whereas others showed SALL4 immunoreactivity in HCC has limited significance (Gonzalez-Roibon et al. 2013; Oikawa et al. 2013; Han et al. 2014). The gene discussed is SALL4; the disease is hepatocellular carcinoma.