The activated signaling pathway and proteins formed by LEP-LEPR linking has been associated with cancer pathogenesis due to interactions with Janus kinase tyrosine (JAK-2), suppressors of cytokine signaling (SOCS), and the signal transducer and activator of transcription-3 (STAT) (Fruhbeck et al. 1998; Ahima and Osei 2004). The gene discussed is LEP; the disease is cancer.