AKT1 and colorectal neoplasm: Combined with the observation that nuclear BCL-3 is associated with poor prognosis in patients with colorectal cancer,22 the fact that BCL-3 expression increased activation of the pro-survival AKT pathway and increased the growth of colorectal tumour cells in mice (xenografts) emphasises the potential importance of BCL-3 in colorectal carcinogenesis.