However, it is important to stress that in the current study AKT activation by BCL-3 was clearly detected in more than one carcinoma cell line (we have detected BCL-3-induced AKT activation in SW480, SW620, HCA7, HT29 and HCT116 cells) as well as RG/C2 adenoma-derived cells. This evidence concerns the gene AKT1 and carcinoma.