The effects of BCL-3 expression on the tumorigenicity of the cells in vivo are shown in figure 1E. Importantly, expression of wtBCL-3 significantly increased tumour size in athymic nude mice from 20 days post inoculation (figure 1E, in agreement with the findings of Liu et al,31 who report that suppression of BCL-3 in the CT26 CRC cell line inhibited tumour growth). This evidence concerns the gene BCL3 and colorectal carcinoma.