Notably, the intensity of BCL-3 expression in colorectal carcinoma tissue was found to be more heterogeneous than in the normal tissue (with regions of high and low expression within the same tumour) although BCL-3 expression was generally increased (consistent with previous reports22, 31), with cytoplasmic staining of BCL-3 a consistent feature in 31 of the 47 colorectal cancer specimens. Here, BCL3 is linked to colorectal cancer.