Contrary to what we observed in the clinical samples, loss of E-cadherin expression in prostate cancer cells in vitro did not alter the expression of DSG2, suggesting that the loss of E-cadherin based adherens junctions in prostate cancer does not result in the reciprocal loss of desmosomes, and that the formation of desmosomes does not strictly require the presence of adherens junctions. The gene discussed is CDH1; the disease is prostate carcinoma.