As loss of adherens junctions does not lead to the reciprocal loss of desmosomes in prostate cancer in vitro, we next examined the effects of PI3K/AKT signaling on anchoring junctions in prostate cancer as this pathway has been shown to lead to the downregulation of E-cadherin and mislocalization of desmosomal proteins in squamous cell carcinoma lines 29. This evidence concerns the gene AKT1 and Familial prostate cancer.