The functional importance of S1R in the nervous system is manifested by the link of its gene defects or reduced protein levels with fronto-temporal lobar degeneration-motor neuron disease5, amyotrophic lateral sclerosis (ALS)6, 7, Alzheimer’s disease (AD)8, 9, 10, Parkinson’s disease (PD)11, and Schizophrenia12 in human patients. The gene discussed is TMBIM4; the disease is amyotrophic lateral sclerosis.