PINX1 and nonpapillary renal cell carcinoma: In validation cohort TMA which contains 278 cases ccRCC tissues and 35 cases normal renal tissues (Figure 1a, top panel), PinX1 low expression staining was observed in 7 of 35 (20%) normal renal tissues, and 168 of 278 (60%) ccRCC tissues (P < 0.001, Figure 1a, bottom panel).