In influenza-infected mice, pretreatment with EGFR inhibitor results in decreased viral infection, decreased macrophage inflammatory protein (MIP)-2, a murine IL-8 homolog, secretion, and decreased neutrophil recruitment but increased IP-10 and IFN-λ secretion in influenza-infected mice (18, 23, 45). This evidence concerns the gene CXCL10 and influenza.