IRF1 and influenza: Previous study shows that EGFR signaling suppresses IRF-1-dependent IP-10 (CXCL-10) and IFN-λ (IL-29) secretion in bronchial epithelial cells (18, 45) and that, in the murine influenza model, EGFR inhibition increases lymphocyte recruitment and results in decreased viral infection through IRF-1 (18, 45).