For example, a recent meta-analysis has demonstrated that elevations in CRP and IL-6 appear to precede the development of depressive disorders,63 and that patients with increased inflammation are less likely to respond to conventional antidepressants,64 and more likely to respond to adjunctive anti-inflammatory treatment.65 Thus, assessment of childhood trauma in conjunction with that of inflammatory markers may prove crucial in developing more effective prevention strategies and treatments, affecting long-term mental health outcomes. Here, IL6 is linked to depressive disorder.