IL6R and arthritic joint disease: To further evaluate the feasibility of mimotopes vaccination approach, the mimotopes of AM16-1 (mAb against murine IL-6R) should be screened and used to immunize the collagen-induced arthritis (CIA) animal models for us to observe whether the mimotopes of AM16-1 could raise antibodies against the murine IL-6R and ameliorate the arthritis in animal models.