MC4R and polycystic ovary syndrome: To investigate the combined effect, we also studied the participants who were simultaneously carrying the risk A and C alleles of FTO or MC4R. The subjects were divided into a group with both risk alleles (simultaneously carrying the risk A and C, PCOS vs. control = 131 vs. 121), a group carrying one risk allele (carrying the risk A or C, PCOS vs. control = 227 vs. 314), and a group with no risk alleles.