In any case, we would like to stress here that we do not rule out the involvement of the transcriptional regulation of the SEMA3C gene in the process of gliomagenesis since, given the heterogeneuos composition of glioma tumor (especially high grade), it is plausible that the active SEMA3C transcription might be going on in a specific subpopulation of cells, such as glioma stem cells [15]. The gene discussed is SEMA3C; the disease is central nervous system cancer.