The development and invasiveness of gliomas are under strong influence by the local microenvironment: a plethora of factors (e.g., VEGF and bFGF) are secreted by tumor cells to affect the local tissue, whereas, in response, brain parenchymal cells secrete ligand molecules to stimulate glioma invasion and/or change the local microenvironment into a more permissive one for the tumor progression [2]. Here, FGF2 is linked to central nervous system cancer.