While searching for alternative explanations of the increase of Sema3C levels in high grade gliomas, we would like to point out that the most predominant 70 kDa Sema3C isoform in our immunoblots most likely represents the cleavage product of Sema3C generated by one of the proteases (e.g., furin-like pro-protein convertase (FPPC) [17] since the full-length Sema3C protein has been reported of 95 kDa in size, which was detected in the human breast cancer cell line MCF7 [5]. Here, SEMA3C is linked to central nervous system cancer.