The notion that Sema3C processing may differ between glioma grades is at some extent supported by our observation that a short, approximately 45 kDa fragment, which was recognized by Sema3C antibody in immunoblots, appeared more often in grade I-III astrocytoma samples rather than in glioblastomas (Additional file 1: Figure S3). Here, SEMA3C is linked to glioblastoma.