In our study, the methylation status of both genes, RB1 and CDH1, increased with the severity of the cervical lesion, suggesting that the frequency of methylation was higher in cancers (50.0% for RB1 and 33.3% for CDH1) than in the other lesions and controls (6.7% for RB1 and 13.3% for CDH1 in controls). The gene discussed is RB1; the disease is cancer.