However, the weight reduction with both liraglutide and roflumilast in the present study was of lesser magnitude when compared to the studies in PCOS population using combined therapies, including combined treatment of GLP-1 receptor agonist [5, 17] and metformin or combination of roflumilast and metformin [10], which might suggest a possible additive role of metformin to GLP-1 mediated effect [19, 20]. The gene discussed is GCG; the disease is polycystic ovary syndrome.