HCFC1 and preeclampsia: Cff-DNA has shown some predictive value for the prediction of preeclampsia between 20 and 25 weeks of gestation, however, higher sensitivities and specificities can be obtained by combining several markers as has been shown in a nested case–control study for cff-DNA combined with Inhibin A in the second (n = 15 at risk for PE, n = 68 controls) and third trimester (n = 34 preeclampsia, n = 44 controls) [22].