The phosphorylation levels of transcription factors NF-κB (p65 subunit) and AP-1 (P-c-Jun) were likewise significantly higher in PSP and LPS group than control group in peritoneal macrophages of B10 (TLR4+/+) mice (all p < 0.05). The gene discussed is TLR4; the disease is supranuclear palsy, progressive, 1.