There were no significant differences in clinical characteristics based on the presence of mild vision loss (VA 20/50 or worse) (N = 26 vs. 20); however AA had more vision loss compared to W (6/7 (86 %) vs. 13/35 (37 %), p = 0.018) (data not shown).Vision loss was associated with higher rates of complications: cataract (p < 0.001), band keratopathy (p < 0.001), cystoid macular edema (p = 0.015) In addition, those with vision loss required the use of more anti-tumor necrosis factor agents (p = 0.042) . This evidence concerns the gene TNF and Cystoid macular dystrophy.