Based on the significance of the distance measurements, the functional proximity between core and candidate genes on the cluster plot and the assumptions of the connectome analysis, LRP1 may have an important role in ADs such as RA, SS and AITD via similar mechanisms, networks and/or pathways as IL10. Evidence for this interpretation is further enhanced by the fact that the individual homozygous for the LRP1 variant contains these precise phenotypes (i.e., RA, SS, AITD). This evidence concerns the gene LRP1 and synovial sarcoma.