The most important PRRs in viral infections are Toll-like receptors (TLRs), RNA helicases (such as retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5)), and double-stranded RNA-dependent protein kinase (PKR) [8,9]. The gene discussed is EIF2AK2; the disease is viral infectious disease.