POLB and cancer: Indeed, anti-apoptosis associated genes IKBKB, POLB, SFRP1 and FNTA, as well as endopeptidase genes ADAM9 and PLAT encoded in the region are both amplified and overexpressed (S1C and S1D Table) (these genes are also recurrently amplified in human cancers including HNSCC according to cBioPortal [44] at www.cbioportal.org).