In order to estimate whether the clinical impact of SOX9 expression in ERG-positive cancers harboring PTEN deletions was independent from established prognostic parameters, we performed four different types of multivariate analyses Scenario 1 evaluated all postoperatively available parameters including pathological tumor stage, pathological lymph node status (pN), surgical margin status, preoperative PSA value and pathological Gleason grade obtained after the morphological evaluation of the entire resected prostate. The gene discussed is KLK3; the disease is cancer.