ERG and cancer: The strongest association between loss of SOX9 and poor outcome was found in the subset of cancers harboring both ERG-fusion and PTEN deletion (p = 0.001, Fig 4E), while SOX9 was unrelated to prognosis in ERG-positive and ERG-negative cancers with normal PTEN status (p = 0.56 and p = 0.73; Fig 4G and 4F) or in ERG-negative cancers with PTEN deletion (p = 0.27; Fig 4H).