In particular, every adenoma found in the DKO group retained RhoA and escaped recombination of the RhoAflox/flox allele (Fig 5G) whereas a portion of the tumors in the RhoAcKO group was completely depleted of RhoA, similar to that of the CCSP-Cre model (Fig 5D and 5G). Here, RHOA is linked to adenoma.