RHOC and breast neoplasm: It was previously shown that RhoC-/- mouse embryonic fibroblasts are able to form Ras-induced colonies in agar, and that RhoC-/- mice can form MMTV-PyMT induced breast tumors [40], but to the best of our knowledge this is the first time RhoC has been shown to be dispensable for Ras-induced tumor formation in vivo.