To examine whether Ror2 is involved in DSS-induced colitis, Ror2fl/fl;CAG-Cre/ERT2Tg and Ror2fl/fl;Mx-CreTg mice were administrated tamoxifen (Ror2CAGΔ/Δ) and pIpC (Ror2MxΔ/Δ), respectively, and then DSS was administrated to these mice. This evidence concerns the gene ROR2 and colitis.