It is noteworthy that LPS-induced production of IL-12a, IL-12b, IL-23a, and IL-6 mRNA was not suppressed in colon CD11c+ DCs from Wnt5aMxΔ/Δ mice (Fig. 6d), which are consistent with the observation that Wnt5aMxΔ/Δ mice showed the phenotypes similar to control mice in DSS-induced colitis (see Figures S4B and C). The gene discussed is ITGAX; the disease is colitis.