Moreover, our in vitro data on a favorable modification of the leptin-to-adiponectin ratio in adipocytes may corroborate some in vivo observations reporting an improvement of the leptin to adiponectin ratio, as well as other parameters related to glycemic control, by a Mediterranean diet supplemented with virgin olive oil in patients with type 2 diabetes [9]. The gene discussed is LEP; the disease is type 2 diabetes mellitus.