ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The exposure of adipocytes to TNF-α, as it may occur upon infiltration of TNF-α-producing leukocytes—mainly monocytes/macrophages—into the adipose tissue in conditions of obesity, causes adipocyte dysfunction, resulting in the acquisition of a proinflammatory state, accompanied by adiponectin suppression [24].