An inverse linear dose-response correlation was observed from pooled 8 studies (p < 0.001), with a 3% (95% CI: 2%-4%) reduction of endometrial cancer risk for each 1 g/ml increase of adiponectin, and a 14% (95% CI: 9%-19%) reduction for each 5 g/ml increase of adiponectin. The gene discussed is ADIPOQ; the disease is endometrial cancer.