Obesity increases the risk of endometrial cancer, with an overall risk ratio of 1.60 (p < 0.0001) per 5 kg/m2 increase in body mass index (BMI) showed by a large meta-analysis [2], which may be caused by insulin resistance, increased sex steroid, chronic systemic inflammation and alterations of the levels of adipocyte-derived factors [3,4]. Here, INS is linked to endometrial cancer.