BMP2 and neoplasm: To examine whether BMP ligands are required by Dragon to induce tumor growth in vivo, we subcutaneously injected CMT93 cells with or without stable Dragon over-expression into C57BL/6 mice, followed by intraperitoneal injection of anti-BMP2/4 antibody or IgG at a dose of 2 μg/g body weight once every 2 days (Figure 7A).