Thus, we investigated if MJ25 kills melanoma cells via inhibition of ALDH1A1 by comparing the effects of MJ25 on p53 activation, cell growth and clonogenic potential to those of disulfiram, which is an inhibitor of ALDH1 and ALDH2 [88] and approved for the treatment of alcoholism [89]. The gene discussed is ALDH2; the disease is alcohol drinking.