For instance, quite recently TRα was found to enhance cancer cell migration and metastasis via inhibition of miR-17 [34] as well as to maintain pro-neoplastic potency by interacting with the cyclin D1/CDK/Rb/E2F cascade [35], the wnt pathway [3] or by inducing CTNNB1 gene expression [23]. Here, RB1 is linked to cancer.