Further, TR positivity was also associated with five-year survival (TRα positivity—reduced five-year survival; TRβ positivity—advanced five-year survival) in ER negative (TRα: p = 0.032; TRβ: p = 0.020), PR negative (TRα: p = 0.011; TRβ: p = 0.029) BRCA1 mutated breast cancer. The gene discussed is ESR1; the disease is breast carcinoma.