ANG and diabetes mellitus: In diabetic animal models, we [12] and others [8,13,14] have demonstrated that the ACE2/Ang-(1–7)/Mas axis plays a beneficial role in attenuating the development of diabetes in association with islet damage; and that it’s activation is associated with improved insulin sensitivity, pancreatic blood flow, and glucose uptake, underscoring the potential of this axis as a therapeutic target for diabetic treatment.