Experimental data suggest that the prevention of endothelial cell damage by growth factors such as vascular endothelial cell growth factor (VEGF), basic fibroblast growth factor (bFGF), and an angiopoietin-1 variant inhibit crypt cell damage, organ failure, and death in radiation-induced gastrointestinal syndrome [6, 7]. Here, FGF2 is linked to radiation-induced gastrointestinal mucositis.