VEGFA and neoplasm: The involvement of TAF-generated PDGF-C in tumor refractoriness was confirmed by arresting its functions using neutralizing antibody, which subsequently ameliorated the TAF-resistant induced angiogenesis and drastically delayed the growth of resistant tumors.16 di Tomaso et al.52 also demonstrated that the stroma-generated PDGF-C overexpression was associated with resistance to anti-VEGF treatment in glioblastoma tumor model studies.52