HIF1A and cancer: HIF-1α mediates the transcription of genes involved in angiogenesis, oxygen consumption, migration and invasion of cancer cells.62 It has been described that anti-angiogenic agents induce ‘vascular regression,' which leads to increase in intratumor hypoxia and selection of more invasive metastatic clones of the cancer cells that are resistant to therapy including anti-angiogenic agents.63 Nevertheless, targeting hypoxia is being prioritized for overcoming the disappointing performance of anti-angiogenic agents in the clinic.62