LDLRAP1 and neoplasm: It was observed previously that ARH1 genotype affected tumorigenesis; ARH1KO and ARH1 heterozygous MEFs, but not ARH1 WT and ARH1KO+WT MEFs developed tumors in nude mice.32 Using ARH1KO MEFs transformed with ARH1 mutant genes, the effects of ARH1 mutant genes and activities of encoded proteins on subcutaneous tumor mass in athymic nude mice were determined.