We did a PUBMED search using the following phrases “insulin receptor”, insulin receptor protein”, “adipose tissue”, “omentum”, “pregnancy”, “pregnancy complications”, “diabetes in pregnancy” and we could not find any report on downregulation of IRS1 in omental compared to subcutaneous tissue in non-obese healthy, nondiabetic pregnant women; consequently we believe that this finding is a contribution to the literature. This evidence concerns the gene IRS1 and diabetes mellitus.