Zhang et al. found that ischemia has no effect on neuronal ASIC1 expression in the hypothalamus but ASIC2 expression and expression of anti-apoptotic proteins Bcl-2 and Bcl-W were upregulated [63], so perhaps ASIC2 takes part in preventing apoptosis induced by cerebral ischemia [63]. Here, ASIC2 is linked to Cerebral ischemia.