In addition to development, coordinated changes in splicing have been observed during myogeneic differentiation (Bland et al., 2010), differentiation of human erythrocyte (Yamamoto et al., 2009), during epithelial mesenchymal transition (Warzecha et al., 2010), during chemically induced cell death (Moore et al., 2010), during cancer metastasis (Lu et al., 2015) and after insulin stimulation (Hartmann et al., 2009). The gene discussed is INS; the disease is cancer.