CD4 and helminthiasis: Although the frequency of CD4+Foxp3+CD25HI T-cells was similar in helminth-infected and non-infected Indonesian children, BCG-specific (and as mentioned, also Plasmodium falciparum-specific) proliferative responses were increased after depletion of CD4+CD25HI T-cells in helminth-infected children only, pointing to differences in suppressive capacity induced by helminth infection (11).