Other data on Tregs in MDR vs. normally resistant (NR)-TB are scarce and conflicting: similar frequencies of circulating CD4+Foxp3+ Tregs were found in MDR-TB patients compared to (NR-)TB patients (112); however, in another study comparing MDR-TB, NR-TB, and non-tuberculous mycobacteria (NTM) infections, increased ex vivo frequencies of Tregs were found in MDR-TB but also in NTM infections compared to NR-TB. This evidence concerns the gene CD4 and tuberculosis.