Also CD8+Foxp3+CD25+ Tregs were demonstrated in the circulation and BAL fluid of TB patients (107); and CD8+LAG-3+CCL4+ Tregs [lymphocyte activation gene-3 (LAG-3); CC chemokine ligand 4 (CCL4)] were shown by histological staining of infected LNs from TB patients (109). This evidence concerns the gene CCL4 and tuberculosis.