NPC1 and infection: In addition to the displacement of Nups, Strunze et al. (2011) also found that the NPC permeability of adenovirus-infected cells increases; infection of cells that had been microinjected with large fluorescent dextrans, which are normally excluded from the nucleus, yielded nuclear localization of the dextran at 3 h post-infection (Strunze et al., 2011).