PSCs enhance the cancer stem cell phenotype of pancreatic cancer cells by inducing the expression of genes such as ABCG2, Nestin and LIN28 leading to an enhanced radio-resistance of pancreatic cancer cells in in vitro and in vivo systems of pancreatic cancer (Hamada et al., 2012; Al-Assar et al., 2014). This evidence concerns the gene NES and familial pancreatic carcinoma.