In addition, mitogen activated protein kinase-activated protein kinase 2 (MK2) is an important substrate of p38 that is associated with heart failure; since cardiac fibrosis and dysfunction are diminished in MK2 knockout mice (Streicher et al., 2010; Scharf et al., 2013) potentially through an involvement of SERCA2 regulation. Here, MAPK14 is linked to heart failure.