HK1 and schizophrenia: Therefore, our finding that the MO3.13 cells showed the greatest number of glycolytic enzyme changes in response to the MK-801 treatment is consistent with the possibility that oligodendrocyte pathology and disturbances in white matter tracts may contribute to the pathophysiology of schizophrenia (Schmitt et al., 2009; Yao et al., 2013).