SLC12A5 and Seizure: The activity-dependent downregulation of KCC2 after NMDA-induced excitotoxicity may lead to appearance of PB-resistance (Lee et al., 2011; Puskarjov et al., 2014a), and pre-clinical animal models of neonatal seizures that do not result in KCC2 downregulation may not be relevant to ischemic seizures.