SLC12A5 and epilepsy: Even in adult models of epilepsy (Deisz et al., 2011, 2014; Campbell et al., 2015), downregulation of KCC2 has been detected in human cortices resected for refractory seizures and in peritumoral neurons in mouse cortical slices, further confirming that KCC2 is the key player in maintaining chloride homeostasis in mature neurons.