HMOX1 and early-onset autosomal dominant Alzheimer disease: Specifically, HO-1, encoded by the HMOX1 gene, is a 32-kDa stress protein, and the induction of the glial HMOX1 gene may lead to pathological brain iron deposition, intracellular oxidative damage, and bioenergetic failure in Alzheimer’s disease and other human CNS disorders such as Parkinson’s disease and schizophrenia (Schipper et al., 2009; Brown, 2011).