CSF3 and Decreased total neutrophil count: Compared to the literature search data showing the rate of grade 3/4 neutropenia between 51 and 91% and FN rate between 9.5 and 17% after all cycles in the population of patients not receiving primary prophylaxis with G-CSF the 53.3% rate of grade 3/4 neutropenia and 13.3% rate of FN observed in our patients already in the first cycle without G-CSF prophylaxis is rather high.