The development of a tumor blood supply through the process of angiogenesis is essential for the growth of tumors and also determines the ability of tumors to metastasize.31 Hypoxia or hypoglycemia that occurs in rapidly growing tumors increases the expression of vascular endothelial growth factor (VEGF), which is a potent permeability factor.36 Newly formed vessels are immature and have increased permeability to macromolecules due to large endothelial cell gaps, incomplete basement membrane, and absent smooth muscle.36,46. This evidence concerns the gene VEGFA and Hypoglycemia.