The study cohort encompasses a retrospective cohort of 110 pancreatobiliary-type and 65 intestinal-type adenocarcinomas, including paired normal tissue and lymph node metastases from a subset of cases, thus providing a thorough characterization of PODXL expression in a wide range of periampullary adenocarcinomas. Here, PODXL is linked to periampullary adenocarcinoma.