In another study, sialofucosylated PODXL was demonstrated to be a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells in vitro, and was also found to be overexpressed, with membranous localization, in 69 % of 105 pancreatic ductal adenocarcinomas [22]. Here, PODXL is linked to familial pancreatic carcinoma.