The tumor suppressor miRNA let-7, inhibits the expression of several oncogenes including HMGA2 and AURKA. 45 Both genes have been suggested to have essential roles in the regulation of self-renewal, differentiation and somatic cell reprogramming.31, 46 Hence, the Lin28B/let-7 regulatory circuit might also have an essential role in cancer stem-like cell regulation. Here, HMGA2 is linked to cancer.