This upregulation of Lin28B has been found to increase the overall risk of mortality and relapse in cancer patients.43 A large body of evidence has also been suggested several oncogenic roles for Lin28B.12, 44 Our tissue microarray results supported this by revealing that Lin28B expression is upregulated in malignant bladder tissues when compared with normal tissues (Figure 2c). The gene discussed is LIN28B; the disease is cancer.