Furthermore, although mH2A1 is highly expressed in normal bladder tissues, it gradually declines with increases in malignant potential of the cancer.7 As these results suggested that the lack of mH2A1 is associated with the occurrence and progression of bladder cancer, we investigated whether the level of mH2A1 expression is associated with acquisition of bladder cancer stem cell-like properties. This evidence concerns the gene MACROH2A1 and urinary bladder carcinoma.