IGFBP5 and neuropathy: In 5- to 6-month-old Igfbp5 transgenic mice, nerve conduction studies of the sciatic nerve [6, 29, 57] revealed that motor nerve conduction velocities (M-NCVs) were reduced by 18 % when compared to controls (P < 0.05; two-tailed Student’s t test) (Fig. 6i), which is compatible with a mild, putatively secondary demyelinating component of the neuropathy.