In patients with acute coronary syndrome undergoing PCI and receiving maintenance prasugrel or ticagrelor therapy for 1 month, apart from a lower degree of PR provided by ticagrelor vs prasugrel, this study demonstrates that i) among prasugrel-treated patients, PR levels are clearly differentiated (higher) in insulin-treated diabetic patients, while they are similar between non-diabetic and non insulin-treated diabetic patients and ii) ticagrelor provides an homogeneous, very strong platelet inhibition, not influenced by DM status or insulin/non-insulin treatment. The gene discussed is INS; the disease is acute coronary syndrome.